ABSTRACT

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease characterized by neurofibrillary tangles resulting from the accumulation of amyloid beta plaques and hyper-phosphorylated microtubule-associated protein in the cell. Experimental models of AD are critical to understanding AD pathology and the development of new therapeutic modalities. However, studies indicate that the data obtained from basic research contribute to clinical studies with very low success rate. Therefore, it is predicted that evaluating the strengths and weaknesses of the models in the literature and carrying out studies with models that cover different aspects of the disease will increase the success of potential treatments. In this review article, pathological and molecular features of different in vivo and in vitro AD models are discussed. In this context, in addition to traditionally used transgenic animal models and methods based on neural differentiation of cancer cells, induced stem cell-derived organoid structures and neural progenitor cell-derived AD models, which are the focus of current cell culture studies, were compared.